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Au Royaume-Uni, il s'agit d'un mГ©dicament dГ©livrГ© uniquement sur ordonnance. Le stimulant est Г©galement utilisГ© hors AMM pour traiter la somnolence associГ©e Г  l'utilisation d'analgГ©siques opioГЇdes dans la gestion de la douleur postopГ©ratoire. Des Г©ruptions cutanГ©es modГ©rГ©es ou graves ont Г©tГ© observГ©es chez les enfants, y compris le syndrome de Stevens-Johnson, chez plus de 2 % des patients. L'American Urological Association a rГ©cemment annoncГ© qu'elle allait soutenir une Г©tude sur les effets du modafinil sur la somnolence diurne due Г  l'apnГ©e obstructive du sommeil. Certaines Г©tudes rapportent une mise en garde sur un risque potentiel d'addiction en cas d'utilisation prolongГ©e. Il y a actuellement beaucoup d'inquiГ©tudes quant Г  l'utilisation du modafinil afin d'obtenir une performance ou un avantage concurrentiel Г  divers endroits. Le trouble du sommeil liГ© au travail postГ© est un trouble du sommeil grave qui peut ГЄtre causГ© par les horaires de certains emplois. Modiodal Modafinil Le modafinil peut interagir avec d'autres mГ©dicaments. Le modafinil est gГ©nГ©ralement pris en une seule dose de 100 mg au coucher. Le modafinil pur est difficile Г  acheter auprГЁs de vendeurs non rГ©glementГ©s. Il n'est pas recommandГ© de l'utiliser dans les quatre heures prГ©cГ©dant le coucher, car il peut provoquer de l'insomnie. Dans les Г©tudes animales, le modafinil a amГ©liorГ© l'Г©veil et la mГ©moire altГ©rГ©e, et s'est avГ©rГ© efficace dans des tГўches plus complexes. Chaque pilule individuelle contient 100 mg de mГ©dicament, ce qui Г©quivaut Г  une dose moyenne de 160 mg prise sur une pГ©riode de deux Г  quatre heures. Cette recherche sur le modafinil est toujours activement Г©tudiГ©e. Il a une demi-vie d'environ 12 heures et se lie trГЁs peu aux rГ©cepteurs cholinergiques. Il s'agit d'un mГ©lange racГ©mique de deux stГ©rГ©oisomГЁres, le R-modafinil et le S-modafinil, qui sont formГ©s dans le corps Г  partir de la mГЄme molГ©cule de dГ©part mais qui diffГЁrent par leur forme et leurs propriГ©tГ©s. Le modafinil est vendu en deux dosages : 400 mg et 600 mg. Prenez-le Г  jeun. Le modafinil a Г©tГ© prescrit pour traiter les problГЁmes d'Г©veil et d'attention chez les patients souffrant de narcolepsie et de troubles du travail postГ© qui ont des difficultГ©s Г  rester Г©veillГ©s pendant la journГ©e.

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